Rapid resolution of protracted febrile myalgia syndrome with anakinra: Report of two cases

Mercan R., Turan A., Bitik B., TUFAN A. , HAZNEDAROĞLU Ş. , GÖKER B.

MODERN RHEUMATOLOGY, cilt.26, sa.3, ss.458-459, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14397595.2014.882221
  • Sayfa Sayıları: ss.458-459


Protracted febrile myalgia syndrome (PFMS) is a very rare but severe manifestation of familial Mediterranean fever (FMF) which is characterized by severe debilitating pain in large muscle groups that may last for several weeks. Colchicine is ineffective and treatment is largely supportive. Demonstration of crucial role of interleukin-1 (IL-1) in the pathogenesis of FMF has increased the use of IL-1 blockers in colchicine resistant or intolerant patients. Herein, we reported successful use of an IL-1 inhibitor, anakinra, in treatment of two patients with PFMS.