The purpose of this study was to reveal the apoptotic cell formation, using histopathological and immunohistochemical methods, in non-pregnant and pregnant New Zealand White rabbits, and in offspring of the pregnant group exposed to GSM modulated signal in 1,800 MHz frequency. Apoptotic cells were detected in the brain, eyes, kidneys, liver, lung, heart, and spleen by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) staining. Histopathological changes were observed in the examined organs. TUNEL positivity was seen in the brain (group VI) and eyes (groups IV and VI). In groups I, II, Ill, and V. the positivity was lesser than 5% and was not taken into account.