Hepatitis Delta Virus Kinetics under the Prenylation Inhibitor Lonafarnib Suggest HDV-Mediated Suppression of HBV Replication


YURDAYDIN C., BOROCHOV N., KALKAN Ç., DEBROY S., KARATAYLI E., WİLLİAMS H., ...More

EASL 2016, 15 April 2016, (Summary Text) identifier

Abstract

We construct the Frobenius structure on a rigid connection $\mathrm{Be}_{\check{G}}$ on $\mathbb{G}_m$ for a split reductive group $\check{G}$ introduced by Frenkel-Gross. These data form a $\check{G}$-valued overconvergent $F$-isocrystal $\mathrm{Be}_{\check{G}}^{\dagger}$ on $\mathbb{G}_{m,\mathbb{F}_p}$, which is the $p$-adic companion of the Kloosterman $\check{G}$-local system $\mathrm{Kl}_{\check{G}}$ constructed by Heinloth-Ng\^o-Yun. By exploring the structure of the underlying differential equation, we calculate the monodromy group of $\mathrm{Be}_{\check{G}}^{\dagger}$ when $\check{G}$ is almost simple (which recovers the calculation of monodromy group of $\mathrm{Kl}_{\check{G}}$ due to Katz and Heinloth-Ng\^o-Yun), and establish functoriality between different Kloosterman $\check{G}$-local systems as conjectured by Heinloth-Ng\^o-Yun. We show that the Frobenius Newton polygons of $\mathrm{Kl}_{\check{G}}$ are generically ordinary for every $\check{G}$ and are everywhere ordinary on $|\mathbb{G}_{m,\mathbb{F}_p}|$ when $\check{G}$ is classical or $G_2$.