Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF BIOCHEMISTRY, cilt.48, sa.3, ss.282-289, 2023 (SCI-Expanded)
Objectives: Given that drug addiction occurs as a result
of complex gene-environment interaction, a number of
studies claimed that cannabinoid receptor 1 (CNR1), fatty
acid amide hydrolase (FAAH), and monoacylglycerol
lipase (MGLL) single nucleotide polymorphisms (SNPs)
are associated with the risk of substance use disorders
such as cannabis, opioids, and, methamphetamine. However, scientific research on genetic susceptibility to synthetic
cannabinoid addiction is limited. In this population-based
case-control study, we aimed to evaluate the genetic
susceptibility to synthetic cannabinoid use disorder in terms
of these three endocannabinoid system genes in the Turkish
population.
Methods: 100 individuals diagnosed with synthetic cannabinoid use disorder according to Diagnostics and Statistical
Manual of Mental Disorders-5 criteria and 100 healthy
volunteers have recruited for the study. Genotyping of the
CNR1 rs1049353, FAAH rs324420, and MGLL rs604300 SNPs
was performed using Real-Time Polymerase Chain Reaction
hybridization probes.
Results: The patient and control groups consist of 98 %
male, 2 % female, 80 % male, and 20 % female individuals,
respectively. The genotype distributions were consistent
with Hardy–Weinberg equilibrium for all SNPs (p>0.05).
FAAH rs324420 and MGLL 604300 SNPs were genotyped for
the first time in the Turkish population, and the variant
allele frequencies were found as 0.205 and 0.085, respectively. Allele frequencies and genotype distributions CNR1
rs1049353, FAAH rs324420, and MGLL rs604300 SNPs were
similar between the patient and control group (p>0.05).
Conclusions: These results indicate that CNR1, FAAH, and
MGLL gene polymorphisms do not influence the risk of
synthetic cannabinoid use disorder in the Turkish
population.
Keywords: CNR1; FAAH; genetic susceptibility; MGLL; synthetic cannabinoids