Electrochemical Characterization and Rapid Voltammetric Determination of Riluzole in Pharmaceuticals and Human Serum

ŞATANA KARA H. E., DOĞAN TOPAL B., ÖZKAN S. A.

ANALYTICAL LETTERS, cilt.44, sa.6, ss.976-990, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1080/00032719.2010.506936
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.976-990
  • Anahtar Kelimeler: Boron-doped diamond, Electrochemical mechanism, Glassy carbon, Riluzole, Voltammetry, BORON-DOPED DIAMOND, PERFORMANCE LIQUID-CHROMATOGRAPHY, ELECTRODES, DERIVATIVES, ELECTROANALYSIS, OXIDATION, BEHAVIOR, REDOX
  • Gazi Üniversitesi Adresli: Evet

Özet

The electrochemical oxidation of riluzole was investigated using cyclic and linear sweep voltammetry. Under optimized conditions, current and concentration showed linear dependence in Britton Robinson buffer at pH 3.00 for boron doped diamond and pH 3.00 phosphate buffers for glassy carbon electrodes. Differential pulse and square wave voltammetry were used for the determination of riluzole levels in serum samples and pharmaceutical formulations. The limit of detections were found as 5.25x10-7M and 8.26x10-8M for glassy carbon electrode and 1.78x10-7M and 8.42x10-8M for boron-doped diamond electrodes, in serum samples, using differential pulse and square wave methods, respectively.