Simultaneous onset of pemphigus vulgaris in two Turkish siblings.

Kavak A., Aydogan I., Gonen S.

The Journal of dermatology, cilt.32, ss.186-8, 2005 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier


The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.