Eosinophilic granuloma one of a triad of diseases under Langerhans' cell histiocytosis as known as Histiocytosis X, is a rare disorder characterized with uncontrolled proliferation of histiocytes, mostly seen among children and adolescents instead of adults. Although the clinical picture is well defined, there are still unclear aspects on etiology, histology and prognosis. Here we are presenting our experiences on a case of eosinophilic granuloma interestingly in an adult patient. She was admitted with back and hip pain. After her diagnosis of sacral spine osteolytic tumor, the biopsy was performed in our clinic and her histopathology was resulted as eosinophilic granuloma. In this paper we are presenting the clinical and hystopathological features of esonophilic granuloma. We aimed to contribute an additional data to the literature on eosinophilic granuloma presented with an atypical localization and age. According to current literature, there are only few reports on both adults and sacrum affected with eosinophilic granuloma.