EFFECT OF DIETHYLNITROSAMINE ON PROSTAGLANDIN-E AND LIPID-PEROXIDATION LEVELS IN RATS LIVER, LUNG AND RENAL TISSUE


ERBAS D., EKMEKCI A., ARICIOGLU A., KOZ M., ULKUER M.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.49, ss.805-807, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 4
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0952-3278(93)90029-v
  • Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Sayfa Sayıları: ss.805-807

Özet

We have investigated the generation of a prooxidant state and effect on prostaglandin E (PGE) levels after administration of diethylnitrosamine (DENA) to rats. Lipid peroxides were assayed by monitoring thiobarbituric acid (TBA) a reactive material. PGE - like activity was assayed by using bioassay procedure. Our results demonstrate that increased lipid peroxide and decreased PGE levels were found in a dose dependent manner in DENA injected groups when compared to control groups. According to these findings, it is suggested that there is a negative correlation between carcinogenic DENA induced lipid peroxidation and PGE in rat's liver, lung, and renal tissue.