EFFECT OF DIETHYLNITROSAMINE ON PROSTAGLANDIN-E AND LIPID-PEROXIDATION LEVELS IN RATS LIVER, LUNG AND RENAL TISSUE

Erbas, D; Ekmekcı, A; Arıcıoglu, A; Koz, M; Ulkuer, MELAHAT

doi:10.1016/0952-3278(93)90029-v

EFFECT OF DIETHYLNITROSAMINE ON PROSTAGLANDIN-E AND LIPID-PEROXIDATION LEVELS IN RATS LIVER, LUNG AND RENAL TISSUE

Atıf İçin Kopyala

Erbas D., Ekmekcı A., Arıcıoglu A., Koz M., Ulkuer M.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.49, sa.4, ss.805-807, 1993 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 49 Sayı: 4
Basım Tarihi: 1993
Doi Numarası: 10.1016/0952-3278(93)90029-v
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.805-807
Gazi Üniversitesi Adresli: Evet

Özet

We have investigated the generation of a prooxidant state and effect on prostaglandin E (PGE) levels after administration of diethylnitrosamine (DENA) to rats. Lipid peroxides were assayed by monitoring thiobarbituric acid (TBA) a reactive material. PGE - like activity was assayed by using bioassay procedure. Our results demonstrate that increased lipid peroxide and decreased PGE levels were found in a dose dependent manner in DENA injected groups when compared to control groups. According to these findings, it is suggested that there is a negative correlation between carcinogenic DENA induced lipid peroxidation and PGE in rat's liver, lung, and renal tissue.