Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

CİLAKER MIÇILI S., ERGÜR B. U., Ozogul C., SARIOĞLU S., BAĞRIYANIK H. A., TUĞYAN K., ...Daha Fazla

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.35, sa.5, ss.373-381, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/10641963.2012.732647
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.373-381
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.