Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model


CİLAKER MIÇILI S., ERGÜR B. U. , Ozogul C., SARIOĞLU S., BAĞRIYANIK H. A. , TUĞYAN K., ...More

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.35, no.5, pp.373-381, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/10641963.2012.732647
  • Title of Journal : CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Page Numbers: pp.373-381

Abstract

In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.