Hydrogen Peroxide-Induced Oxidative Damage in Human Chondrocytes: The Prophylactic Effects of Hypericum Perforatum Linn Extract on Deoxyribonucleic Acid Damage, Apoptosis and Matrix Remodeling by a Disintegrin-Like and Metalloproteinase With Thrombospondin Motifs Proteinases

Creative Commons License

Akyol S., Yukselten Y., Cakmak O., Ugurcu V., Altuntas A., GÜRLER M., ...Daha Fazla

ARCHIVES OF RHEUMATOLOGY, cilt.29, sa.3, ss.203-214, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 29 Konu: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5606/archrheumatol.2014.5203
  • Sayfa Sayıları: ss.203-214


Objectives: This in vitro study aimed to examine the protective roles of Hypericum perforatum Linn (HPL) extract on cell viability, DNA damage, apoptosis and a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) proteins in chondrocytes induced by hydrogen peroxide (H2O2), as a model of chondrocytes subjected to reactive oxygen species attack in rheumatoid arthritis and osteoarthritis.