Hydrogen Peroxide-Induced Oxidative Damage in Human Chondrocytes: The Prophylactic Effects of Hypericum Perforatum Linn Extract on Deoxyribonucleic Acid Damage, Apoptosis and Matrix Remodeling by a Disintegrin-Like and Metalloproteinase With Thrombospondin Motifs Proteinases

Akyol, Sumeyya; Yukselten, Yunus; Cakmak, Ozlem; Ugurcu, Veli; Altuntas, Aynur; GÜRLER, MUKADDES; Akyol, Omer; Demircan, Kadir

doi:10.5606/archrheumatol.2014.5203

Hydrogen Peroxide-Induced Oxidative Damage in Human Chondrocytes: The Prophylactic Effects of Hypericum Perforatum Linn Extract on Deoxyribonucleic Acid Damage, Apoptosis and Matrix Remodeling by a Disintegrin-Like and Metalloproteinase With Thrombospondin Motifs Proteinases

Atıf İçin Kopyala

Akyol S., Yukselten Y., Cakmak O., Ugurcu V., Altuntas A., GÜRLER M., ...Daha Fazla

ARCHIVES OF RHEUMATOLOGY, cilt.29, sa.3, ss.203-214, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 3
Basım Tarihi: 2014
Doi Numarası: 10.5606/archrheumatol.2014.5203
Dergi Adı: ARCHIVES OF RHEUMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.203-214
Anahtar Kelimeler: A disintegrin-like and metalloproteinase with thrombospondin motifs, apoptosis, hydrogen peroxide, Hypericum perforatum, OUMS-27, ST-JOHNS-WORT, FLAVONOID-RICH EXTRACT, FREE-RADICALS, ANTIOXIDANT ACTIVITY, SYNOVIAL-FLUID, NADPH OXIDASE, DNA DAMAGE, INHIBITION, INFLAMMATION, IDENTIFICATION
Gazi Üniversitesi Adresli: Evet

Özet

Objectives: This in vitro study aimed to examine the protective roles of Hypericum perforatum Linn (HPL) extract on cell viability, DNA damage, apoptosis and a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) proteins in chondrocytes induced by hydrogen peroxide (H2O2), as a model of chondrocytes subjected to reactive oxygen species attack in rheumatoid arthritis and osteoarthritis.