Relationship of serum HLA-B alleles and TNF-α with rheumatic heart disease

Eyiol A., Yayla C., Ünlü S., Tufan A., Cemri M., Yalcin R., ...More

Turkish journal of medical sciences, vol.48, no.4, pp.724-729, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1707-58
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.724-729


Background/aim: Acute rheumatic fever and rheumatic heart disease are major causes of morbidity and mortality in developing countries. Genetic studies have determined that the immune response in rheumatic heart disease is genetically controlled and that there is a close relationship between the gene of concern and the class II human leukocyte antigen (HLA) gene. The aim of this study was to evaluate the relationship of serum HLA-B alleles and tumor necrosis factor alpha (TNF-alpha) with rheumatic heart disease.