INTERACTION OF NAPROXEN WITH BETA-CYCLODEXTRIN IN GROUND MIXTURE


CELEBI N., ERDEN N.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.78, ss.183-187, 1992 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0378-5173(92)90369-d
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Sayfa Sayıları: ss.183-187

Özet

The purpose of the present study was to investigate the interaction of naproxen (NAP) with beta-cyclodextrin (beta-CD) in ground mixtures. The effects of grinding on the physicochemical properties of NAP were studied by means of IR spectroscopy and X-ray diffraction analysis. Ground mixtures of NAP with beta-CD and microcrystalline cellulose (MCC) were prepared by grinding a ceramic ball mill. The dissolution rate of NAP from the ground mixtures was significantly greater than that from physical mixtures and intact NAP powder. The ground mixture with beta-CD showed the fastest dissolution profile. These results indicate that beta-CD can enhance the dissolution rate of NAP.