INTERACTION OF NAPROXEN WITH BETA-CYCLODEXTRIN IN GROUND MIXTURE

CELEBI N., ERDEN N.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.78, ss.183-187, 1992 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0378-5173(92)90369-d
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-187
  • Anahtar Kelimeler: GROUND MIXTURE, BETA-CYCLODEXTRIN, NAPROXEN, MICROCRYSTALLINE CELLULOSE, DISSOLUTION PROFILE, MICROCRYSTALLINE CELLULOSE, PHARMACEUTICAL INTERACTIONS, PHYSICAL CHARACTERISTICS, DISSOLUTION PROPERTIES, ORAL BIOAVAILABILITY, MOLECULAR BEHAVIOR, INCLUSION COMPLEX, DOSAGE FORMS, ASPIRIN, CRYSTALLINITY
  • Gazi Üniversitesi Adresli: Hayır

Özet

The purpose of the present study was to investigate the interaction of naproxen (NAP) with beta-cyclodextrin (beta-CD) in ground mixtures. The effects of grinding on the physicochemical properties of NAP were studied by means of IR spectroscopy and X-ray diffraction analysis. Ground mixtures of NAP with beta-CD and microcrystalline cellulose (MCC) were prepared by grinding a ceramic ball mill. The dissolution rate of NAP from the ground mixtures was significantly greater than that from physical mixtures and intact NAP powder. The ground mixture with beta-CD showed the fastest dissolution profile. These results indicate that beta-CD can enhance the dissolution rate of NAP.