The purpose of the present study was to investigate the interaction of naproxen (NAP) with beta-cyclodextrin (beta-CD) in ground mixtures. The effects of grinding on the physicochemical properties of NAP were studied by means of IR spectroscopy and X-ray diffraction analysis. Ground mixtures of NAP with beta-CD and microcrystalline cellulose (MCC) were prepared by grinding a ceramic ball mill. The dissolution rate of NAP from the ground mixtures was significantly greater than that from physical mixtures and intact NAP powder. The ground mixture with beta-CD showed the fastest dissolution profile. These results indicate that beta-CD can enhance the dissolution rate of NAP.