Since 1975, there has been a great deal of interest, particularly during the past decade, in the promising genetic algorithm (GA) and its application to various disciplines from medicine to cogeneration. However, the studies performed on energy-related GA modeling are relatively low in numbers. The main objective of the present study is to develop the exergy input/output estimation equations in order to estimate the future projections based on the GA notion. In this regard, the GA Future Total EXergy Input/Output Estimation Models (GAFTEXIEM/GAFTEXOEM) are used to estimate total exergy input/output demand of Turkey, which is selected as an application country, based on the economic and social indicators of gross domestic product (GDP), population, import, export and house production figures. The future prediction of Turkey's total exergy input/output values are projected between 2003 and 2023. It may be concluded that the models proposed here can be used as an alternative solution and estimation techniques to available estimation techniques. It is also expected that this study will be helpful in developing highly applicable and productive planning for energy policies.