Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-alpha, Smad1 and TGF-beta 1 genes in a rat model of lung ischemia/reperfusion

Simsek H., DEMİRYÜREK Ş., DEMİR T., Atabay H. D., ÇERİBAŞI A. O., Bayraktar R., ...More

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.19, no.2, pp.209-214, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 2
  • Publication Date: 2016
  • Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.209-214
  • Keywords: Apoptosis, Growth factors, Ischemia/reperfusion, Lung, ISCHEMIA-REPERFUSION INJURY, BONE MORPHOGENETIC PROTEIN-2, EMERGING ROLES, TGF-BETA, APOPTOSIS, PATHWAY, GROWTH
  • Gazi University Affiliated: Yes

Abstract

Objective(s): Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. Lung damage induced by ischemia/reperfusion (I/R) is a frequent problem in lung transplantation. Apoptosis (programmed cell death) is known as cell suicide, and plays a key role in embryonic developmental and in maintain adult tissue's life.