Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice

Kupeli E., Orhan D., Yesilada E.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.103, sa.3, ss.455-460, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jep.2005.08.038
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.455-460
  • Anahtar Kelimeler: Cistus laurifolius, Cistaceae, flavonoid, hepatotoxicity, lipid peroxidation, serum transaminase enzymes, cellular GSH, TRADITIONAL MEDICINE, FOLK MEDICINE, ETHER, LIVER, QUERCETIN, ASPARTATE, AGLYCONES, TURKEY
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, the effect of the flavonoids quercetin-3-methyl-ether-(isorhamnetin) (1). quercetin-3,7-dimethyl-ether (2) and kaempferol-3,7-dimethyl-ether (3) isolated from Cistus laurifolius L. (cistaceae) leaves was assessed oil lipid peroxidation (fiver and plasma), cellular glutathione (GSH) level and plasma AST (aspartate aminotransferase), ALT (alanine aminotransferase) enzyme activities in acetaminophen-induced liver damage in mice. At 114 mg/kg oral dose quercetin-3,7-dimethyl-ether was shown to possess potent antioxidative activity. (c) 2005 Elsevier Ireland Ltd. All rights reserved.