Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice


Kupeli E., Orhan D., Yesilada E.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.103, sa.3, ss.455-460, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 103 Konu: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jep.2005.08.038
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Sayfa Sayıları: ss.455-460

Özet

In this study, the effect of the flavonoids quercetin-3-methyl-ether-(isorhamnetin) (1). quercetin-3,7-dimethyl-ether (2) and kaempferol-3,7-dimethyl-ether (3) isolated from Cistus laurifolius L. (cistaceae) leaves was assessed oil lipid peroxidation (fiver and plasma), cellular glutathione (GSH) level and plasma AST (aspartate aminotransferase), ALT (alanine aminotransferase) enzyme activities in acetaminophen-induced liver damage in mice. At 114 mg/kg oral dose quercetin-3,7-dimethyl-ether was shown to possess potent antioxidative activity. (c) 2005 Elsevier Ireland Ltd. All rights reserved.