Investigation of the Effect of Alemtuzumab in an Experimental Spinal Cord Trauma Model in Rats

Suner H. I., KURT G., Yildirim Z., Bulduk E. B., BÖRCEK A. Ö., Demirci H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.121, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.wneu.2018.09.197
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Alemtuzumab, Anti-inflammatory, Antioxidants, Oxidative stress, Spinal cord injury, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, METHYLPREDNISOLONE, NEUROPROTECTION, INFLIXIMAB, MECHANISM, EMPHASIS, RECOVERY, BREAST
  • Gazi Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Spinal cord injuries generate the most negative response to medical treatment among all general body injuries. This important morbidity is thought to be caused by a complex secondary damage mechanism. In the present study, we examined the neuroprotective effects of alemtuzumab in a spinal cord trauma model.