Investigation of the Effect of Alemtuzumab in an Experimental Spinal Cord Trauma Model in Rats

Suner, Halil; KURT, GÖKHAN; Yildirim, Zuhal; Bulduk, Erkut; BÖRCEK, ALP; Demirci, Harun; Kartal, Bahar; TAKE KAPLANOĞLU, GÜLNUR

doi:10.1016/j.wneu.2018.09.197

Investigation of the Effect of Alemtuzumab in an Experimental Spinal Cord Trauma Model in Rats

Suner H. I., KURT G., Yildirim Z., Bulduk E. B., BÖRCEK A. Ö., Demirci H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.121, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 121
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.wneu.2018.09.197
Dergi Adı: WORLD NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Alemtuzumab, Anti-inflammatory, Antioxidants, Oxidative stress, Spinal cord injury, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, OXIDATIVE STRESS, METHYLPREDNISOLONE, NEUROPROTECTION, INFLIXIMAB, MECHANISM, EMPHASIS, RECOVERY, BREAST
Gazi Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Spinal cord injuries generate the most negative response to medical treatment among all general body injuries. This important morbidity is thought to be caused by a complex secondary damage mechanism. In the present study, we examined the neuroprotective effects of alemtuzumab in a spinal cord trauma model.