High Dose Cotinine may Induce Neural Tube Defects in a Chick Embryo Model

Dalgic A., Armagan E., Helvacioblu F., Okay O., Daglioglu E., Take G., ...More

TURKISH NEUROSURGERY, vol.19, no.3, pp.224-229, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2009
  • Title of Journal : TURKISH NEUROSURGERY
  • Page Numbers: pp.224-229


AIM: Nicotine is a well-known agent among 4000 chemicals in cigarettes. About 70 to 80% of nicotine is converted to cotinine, a major metabolite. The aim of the present study is to investigate the effect of cotinine on neural tube development in a chick embryo model.