High Dose Cotinine may Induce Neural Tube Defects in a Chick Embryo Model

Dalgic, Ali; Armagan, Ercan; Helvacioblu, Fatma; Okay, Oender; Daglioglu, Ergun; Take, GÜLNUR; Unlu, Agahan; Belen, Deniz

High Dose Cotinine may Induce Neural Tube Defects in a Chick Embryo Model

Dalgic A., Armagan E., Helvacioblu F., Okay O., Daglioglu E., Take G., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.19, sa.3, ss.224-229, 2009 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 3
Basım Tarihi: 2009
Dergi Adı: TURKISH NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.224-229
Anahtar Kelimeler: Nicotine, Cotinine, Chick embryo, Neural tube defect, Congenital malformation, MATERNAL SMOKING, CIGARETTE-SMOKE, TOBACCO-SMOKE, NICOTINE, EXPOSURE, METABOLISM, GROWTH
Gazi Üniversitesi Adresli: Evet

Özet

AIM: Nicotine is a well-known agent among 4000 chemicals in cigarettes. About 70 to 80% of nicotine is converted to cotinine, a major metabolite. The aim of the present study is to investigate the effect of cotinine on neural tube development in a chick embryo model.