Essential oils of Origanum minutiflorum, Sideritis erytrantha subsp. erytrantha, Satureja wiedemanniana, Salvia tchihatcheffii and Thymus sipyleus subsp. sipyleus were tested against Xanthomonas vesicatoria, the agent of bacterial spot of tomato. Essential oil yields of these endemic plants were between 0.35-4.40% v/w per 100 g plant material. Essential oils inhibition zones, measured with calipers, were in the range of 4-43 mm. The lowest minimum inhibitory concentration (MIC) value against X. vesicatoria of essential oil was that of O. minutiflorum (200 mu g/ml). The major constituents of the oils determined by GC-MS technique were carvacrol (C10H14O), gamma-terpinene (C10H16), p-cymene (C10H14) and 1.8-cineole (C10H18O). The essential oil of O. minutiflorum reduced bacterial spot severity significantly (81.25%).