COMPARISON OF ORGANIC SOLVENTS USED FOR THE DETERMINATION OF MUSTARD GAS HYDROLYSIS PRODUCTS IN URINE SAMPLES USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY


Kenar L., ALP O.

ANALYTICAL LETTERS, vol.43, no.3, pp.417-423, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1080/00032710903402564
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.417-423
  • Keywords: Ethyldiethanolamine, Gas chromatography mass spectrometry, Methyldiethanolamine, Nitrogen mustard, CHEMICAL WARFARE AGENTS, WEAPONS CONVENTION, NITROGEN MUSTARDS, SULFUR-MUSTARD, DERIVATIZATION, VERIFICATION, QUANTIFICATION, THIODIGLYCOL, DERIVATIVES, EXTRACTION
  • Gazi University Affiliated: Yes

Abstract

This study aimed to optimize a method for determining N-ethyldiethanolamine (EDEA) and N-methyldiethanolamine (MDEA) in urine samples using gas chromatography-mass spectrometry. The analytes were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and the most proper organic solvent was investigated. Best recoveries were found for acetonitrile and dimethylsulphoxide. The recoveries of spiked samples (100 ng ml(-1)) were found as 108 +/- 5.7% for EDEA and 97 +/- 6.4 for MDEA. The limit of detection (LOD, S/N = 3) values were 0.5 ng ml(-1) and 0.4 ng ml(-1) for EDEA and MDEA, respectively. The precision of the method in terms of RSD was between 5-8%.