TURKISH NEUROSURGERY, vol.28, no.1, pp.105-110, 2018 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
Spinal cord injury, Quetiapine, Apoptosis, Secondary damage, EARLY ULTRASTRUCTURAL FINDINGS, LIPID-PEROXIDATION, CELL-DEATH, APOPTOSIS, RATS, SARPOGRELATE, ERYTHROPOIETIN, ANTAGONIST, MODELS
AIM: It is well known that treatment modalities against secondary damage due to spinal cord injury (SCI) are very important. This phase has been researched in many experimental studies. Apoptosis is one of the major mechanisms of secondary damage on spinal cord. The present study was undertaken to determine if quetiapine, a 5-HT2 receptor blocker atypical antipsychotic agent can rescue neuronal cells from apoptosis in a SCI model.