Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats

Yesilada E., Takaishi Y., Fujita T., Sezik E.

JOURNAL OF ETHNOPHARMACOLOGY, vol.70, no.3, pp.219-226, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 3
  • Publication Date: 2000
  • Doi Number: 10.1016/s0378-8741(99)00180-4
  • Journal Name: JOURNAL OF ETHNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.219-226
  • Gazi University Affiliated: No

Abstract

Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.