Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats

Yesilada E., Takaishi Y., Fujita T., Sezik E.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.70, sa.3, ss.219-226, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 3
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0378-8741(99)00180-4
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-226
  • Gazi Üniversitesi Adresli: Hayır

Özet

Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.