Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin-diabetic rats: Role of oxidative/nitrosative stress

Cumaoglu A., Cevik C., Rackova L., ARI N., KARASU Ç.

BIOFACTORS, cilt.30, sa.3, ss.171-178, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/biof.5520300304
  • Dergi Adı: BIOFACTORS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.171-178
  • Anahtar Kelimeler: diabetes, protein oxidation, stobadine, carbonyl, thiol, oxidative stress, nitrosative stress, advanced oxidation protein products, nitrotyrosine, VITAMIN-E, LIPID-PEROXIDATION, PYRIDOINDOLE STOBADINE, CHEMICAL-MODIFICATION, IN-VITRO, COMPLICATIONS, GLYCATION, PEROXYNITRITE, MELLITUS, ALBUMIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Increased oxidative/nitrosative stress is important in the pathogenesis of diabetic complications, and the protective effects of antioxidants are a topic of intense research. The purpose of this study was to investigate whether a pyridoindole antioxidant stobadine (STB) have a protective effect on tissue oxidative protein damage represented by the parameters such as protein carbonylation (PC), protein thiol (P-SH), total thiol (T-SH) and non-protein thiol (Np-SH), nitrotyrosine (3-NT), and advanced oxidation protein products (AOPP) in streptozotocin-diabetic rats.