HUMORAL IMMUNE-RESPONSE AGAINST ANTIGEN-60 IN BCG-VACCINATED INFANTS

ROTA S., BEYAZOVA U., KARSLIGIL T., CEVHEROGLU C.

EUROPEAN JOURNAL OF EPIDEMIOLOGY, cilt.10, sa.6, ss.713-718, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 6
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1007/bf01719287
  • Dergi Adı: EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.713-718
  • Anahtar Kelimeler: ANTIGEN 60, BCG, IMMUNE RESPONSE, INFANTS
  • Gazi Üniversitesi Adresli: Hayır

Özet

An ELISA assay based on the A-60 antigen complex from Mycobacterium bovis BCG cytoplasm was used to detect anti-mycobacterial antibodies of different classes in the sera of 63 BCG-vaccinated infants during the 6-month post-vaccination period. The mean IgM and IgA levels increased, whereas the mean IgG level decreased after BCG vaccination. However, in a minority of cases only Ig levels were above the cut-off line: this was true for IgM in 11/63 (17%) cases and for IgA in 14/63 (22%) of cases but none of the tested infants was anti-A60 IgG ELISA positive. Fifty-two infants (83%) were tuberculin-positive eight weeks after vaccination, and no significant difference in mean antibody levels of tuberculin-positive and negative cases was observed, except for IgG (p < 0.05).