Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever

Haznedaroglu S., Ozturk M., Sancak B., Goker B., Onat A., Bukan N., ...More

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.23, no.4, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2005
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: familial Mediterranean fever, interleukin 17, interleukin 18, INTERFERON-GAMMA, TH2 CELLS, IL-17, ACTIVATION, CYTOKINES
  • Gazi University Affiliated: Yes

Abstract

Objective. Familial Mediterranean fiver (FMF) attacks are characterized by serosal inflammation rich in PMNL leukocytes and activation of a definite cytokine network. Moreover there is sustained inflammation in attack-free FMF patients. Interleukin (IL)-17 and IL-18 art recently described proinflammatory cytokines, which Can modulate certain neutrophil functions. fit this study we measured serum levels of IL-17 and IL-18 in FMF patients.