Investigation of the effects of stobadine on the antioxidant enzymes in carbon tetrachloride mediated brain toxicity


BAYRAKTAR N., Devay S. D. , Taslipinar M. Y. , Ucankus N. L. , Omeroglu S., Gumuslu S., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.36, sa.4, ss.283-289, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Konu: 4
  • Basım Tarihi: 2011
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.283-289

Özet

Objectives: The aim of the present study was to investigate the relation between brain damage induced by carbon tetrachloride and superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase enzyme activities. Also, the other aim was to evaluate the effect of stobadine on this metabolism. We particularly choose brain tissue as an experimental model because it contains reach polyunsaturated fatty acids which is one of the most important targets of the free radicals. Another important reason for choosing brain as a model is the limited studies with brain tissue damaged with carbon tetrachloride that compared to numerous ones with hepatic tissue.