Investigation of the effects of stobadine on the antioxidant enzymes in carbon tetrachloride mediated brain toxicity


BAYRAKTAR N., Devay S. D. , Taslipinar M. Y. , Ucankus N. L. , Omeroglu S., Gumuslu S., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.36, no.4, pp.283-289, 2011 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 2011
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.283-289

Abstract

Objectives: The aim of the present study was to investigate the relation between brain damage induced by carbon tetrachloride and superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase enzyme activities. Also, the other aim was to evaluate the effect of stobadine on this metabolism. We particularly choose brain tissue as an experimental model because it contains reach polyunsaturated fatty acids which is one of the most important targets of the free radicals. Another important reason for choosing brain as a model is the limited studies with brain tissue damaged with carbon tetrachloride that compared to numerous ones with hepatic tissue.