Synthesis of 2(3H)-benzothiazolinone derivatives as analgesic and anti-inflammatory agents


DÜNDAR Y. , Çakir B., Küpeli E., ŞAHİN M. G.

Turkish Journal of Pharmaceutical Sciences, cilt.3, sa.2, ss.51-60, 2006 (SCI Expanded İndekslerine Giren Dergi) identifier

  • Cilt numarası: 3 Konu: 2
  • Basım Tarihi: 2006
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Sayfa Sayıları: ss.51-60

Özet

In this study, we have synthesized new 1-(4-(2-oxobenzothiazolin-3-yl) butyl-4-substituted piperazine, 1-(4-(2-oxobenzothiazolin-3-yl)butanoyl-4- substituted piperazine and 3-(4-(2-oxo-1,3-benzothiazol-2(3H)-yl)butyl)-1,3- benzothiazol-2(3H)-one derivatives and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in animals. The chemical structures of these compounds were elucidated by their IR, 1H-NMR spectral data, and elementel analyses. None of the compounds except compound 5b, 5c caused gastric lesions or bleeding in test animals. Compound 6c was found to have the highest analgesic and anti-inflammatory activity among the synthesized compounds.