Objective: In patients with refractory septic shock corticosteriod therapy has been shown to improve hemodynamic instability. This has been named as critical illness related adrenal insufficiency. Several studies had been done on significane of cotricosteriod treatment in vasopressor dependent patients. As well it is recommended in guidelines. The aim of this study was to study the effects of plasma cortisol levels and corticosteroid therapy on intensive care unit(ICU) mortality of the patients.