This work was focused on the neutronic calculation of the nuclear parameters (neutron spectrum, displacement per atom (DPA), gas production, tritium breeding ratio (TBR), nuclear heating) for structural materials in the first wall (FW) and fuel clad (made of ferritic/martensitic steels, vanadium alloy, silicon carbide, copper alloy, and stainless steel) of an experimental hybrid reactor using the most current Monte Carlo Neutron-Particle Transport code MCNP5 1.4. Neutronic calculations were performed using a (DT) fusion driver hybrid reactor under a neutron wall loud of 2.25 MW/m(2) by full reactor power for one year. Obtained results were compared with three different data libraries (ENDF/B-V, ENDF/B-VI and CLAW-IV). TBR values in the reactor blanket for all investigated materials became greater than the minimum requirement (TBR > 1.05). Nuclear parameters like DPA, He-production and nuclear heating were considered as radiation damage limits for structural materials, copper alloy (Cu0.5Cr0.3Zr) showed better performance than all investigated materials. (c) 2007 Elsevier Ltd. All rights reserved.