Levels of Glucagon-like Peptide 1 are Decreased in Macrosomic Neonates from Non-Diabetic Mothers

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Aktulay A., Engin-Ustun Y., Yasar O. G., YILMAZ C., Erkaya S., Ozgu-Erdinc A. S.

ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE, cilt.223, sa.1, ss.48-53, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 223 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1055/a-0660-9734
  • Dergi Adı: ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.48-53
  • Anahtar Kelimeler: Glucagon-like peptide 1, macrosomia, GESTATIONAL DIABETES-MELLITUS, SECRETION, GLUCOSE, OBESITY, GLP-1, POLYPEPTIDE, OVERGROWTH, TRENDS, TARGET, ALPHA
  • Gazi Üniversitesi Adresli: Evet

Özet

Glucagon-like peptide 1 (GLP-1) is a gut-derived peptide with insulin-like effects. Our aim was to analyze cord blood GLP-1 levels of macrosomic and appropriate-gestational-age (AGA) neonates from non-diabetic mothers. A case-control study was conducted with 22 term macrosomic neonates (birth weight >= 4000 g) and 22 AGA (birth weight > 10th percentile and < 4000 g) pregnancies. Cord blood GLP-1 levels of neonates were measured. There were no significant differences in maternal age, gestational age and gravida between the 2 groups. Umbilical cord blood GLP-1 levels were significantly lower in macrosomic neonates (6.9 +/- 2.9 pg/mL) compared with control group (10.3 +/- 3.7 pg/mL) (p = 0.002). Binary logistic regression analysis showed only the maternal BMI to be an independent statistically significant predictor of macrosomia (odds ratio = 2.459; 95 % CI, 1.170-5.170; P = 0.018). The results of our study revealed decreased GLP-1 levels in macrosomic neonates, and maternal BMI was an independent predictor of macrosomia.