Crude extracts prepared from fresh-water macroalgae, Cladophora fracta (Dilw.) Kütz, C. glomerata (Dilw.) Kütz, Spyrogyra gratiana Link., and Maugeotia sp. (C.A. Agardh) Wittrock, along with two aqueous plants, Elodea canadensis Michx. and Ranunculus rionii Lagger have been investigated for their antimycobacterial activity. The results of the crude extracts are described in this study.