The relationship of osteopontin and related cytokin levels with disease activity, treatment and comorbidities in psoriasis vulgaris

Bulur I., GÜLEKON A., ERDEM O. A., Yucel A., Celik S., Aral A.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.47, sa.3, ss.142-147, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4274/turkderm.55798
  • Dergi Adı: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.142-147
  • Anahtar Kelimeler: Psoriasis, osteopontin, cytokine, NECROSIS-FACTOR-ALPHA, T-CELLS, GROWTH-FACTOR, MECHANISMS, LESIONS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background and Design: The IL23/Th17 axis is an exciting new pathway in the pathogenesis of psoriasis. Osteopontin (OPN) is a recently defined phosphorylated acidic glycoprotein which has an effect on psoriasis, especially over Th1/Th17 cells. We aimed to understand the role of OPN and Th1/Th17 pathway in the immunopathogenesis of psoriasis, to assess its relationship with disease severity and to introduce the potential target molecules for therapeutic intervention in psoriatic patients. Materials and