The relationship of osteopontin and related cytokin levels with disease activity, treatment and comorbidities in psoriasis vulgaris
TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.47, sa.3, ss.142-147, 2013 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 3
- Basım Tarihi: 2013
- Doi Numarası: 10.4274/turkderm.55798
- Dergi Adı: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.142-147
- Anahtar Kelimeler: Psoriasis, osteopontin, cytokine, NECROSIS-FACTOR-ALPHA, T-CELLS, GROWTH-FACTOR, MECHANISMS, LESIONS
- Gazi Üniversitesi Adresli: Evet
Özet
Background and Design: The IL23/Th17 axis is an exciting new pathway in the pathogenesis of psoriasis. Osteopontin (OPN) is a recently defined phosphorylated acidic glycoprotein which has an effect on psoriasis, especially over Th1/Th17 cells. We aimed to understand the role of OPN and Th1/Th17 pathway in the immunopathogenesis of psoriasis, to assess its relationship with disease severity and to introduce the potential target molecules for therapeutic intervention in psoriatic patients. Materials and