The relationship of osteopontin and related cytokin levels with disease activity, treatment and comorbidities in psoriasis vulgaris


Bulur I., GÜLEKON A. , ERDEM O. A. , Yucel A. A. , Celik S., Aral A.

TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY, vol.47, no.3, pp.142-147, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.4274/turkderm.55798
  • Title of Journal : TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
  • Page Numbers: pp.142-147

Abstract

Background and Design: The IL23/Th17 axis is an exciting new pathway in the pathogenesis of psoriasis. Osteopontin (OPN) is a recently defined phosphorylated acidic glycoprotein which has an effect on psoriasis, especially over Th1/Th17 cells. We aimed to understand the role of OPN and Th1/Th17 pathway in the immunopathogenesis of psoriasis, to assess its relationship with disease severity and to introduce the potential target molecules for therapeutic intervention in psoriatic patients. Materials and