Topical Wound-Healing Effects and Phytochemical Composition of Heartwood Essential Oils of Juniperus virginiana L., Juniperus occidentalis Hook., and Juniperus ashei J. Buchholz

Creative Commons License

TÜMEN İ., SÜNTAR İ., Eller F. J., KELEŞ H., AKKOL E.

JOURNAL OF MEDICINAL FOOD, cilt.16, sa.1, ss.48-55, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1089/jmf.2012.2472
  • Dergi Adı: JOURNAL OF MEDICINAL FOOD
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.48-55
  • Anahtar Kelimeler: anti-inflammatory, essential oil, heartwood, Juniperus, medicinal plant, wound healing, RETICULITERMES-FLAVIPES KOLLAR, FORMOSAN SUBTERRANEAN TERMITE, SUPERCRITICAL CARBON-DIOXIDE, EASTERN-RED-CEDAR, TRADITIONAL MEDICINE, CHEMICAL-COMPOSITION, FOLK MEDICINE, UNITED-STATES, BARK SAPWOOD, ANTIOXIDANT
  • Gazi Üniversitesi Adresli: Evet

Özet

Ethnobotanical surveys indicated that in the traditional medicines worldwide, several Juniperus species are utilized as antihelmintic, diuretic, stimulant, antiseptic, carminative, stomachic, antirheumatic, antifungal, and for wound healing. In the present study, essential oils obtained from heartwood samples of Juniperus virginiana L., Juniperus occidentalis Hook. and Juniperus ashei J. Buchholz were evaluated for wound healing and anti-inflammatory activities by using in vivo experimental methods. The essential oils were obtained by the supercritical carbon dioxide extraction method. Linear incision and circular excision wound models were performed for the wound-healing activity assessment. The tissues were also evaluated for the hydroxyproline content as well as histopathologically. To evaluate the anti-inflammatory activity of the essential oils, the test used was an acetic acid-induced increase in capillary permeability. The essential oil of J. occidentalis showed the highest activity on the in vivo biological activity models. Additionaly, the oil of J. virginiana was found highly effective in the anti-inflammatory activity method. The experimental data demonstrated that essential oil of J. occidentalis displayed significant wound-healing and anti-inflammatory activities.