The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle


Ademoglu F., Basgut B., Abacioglu N., Cakici I.

PHARMACOLOGY, vol.66, no.1, pp.1-4, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1159/000065311
  • Title of Journal : PHARMACOLOGY
  • Page Numbers: pp.1-4

Abstract

We have previously reported that peroxynitrite (ONOO-) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO- (0.03-1.0 mmol/l)-induced relaxations were reduced significantly by the presence of an ATP-sensitive potassium channel (K-ATP(+) channel) blocker, glibenclamide (0.3 mumol/1), or 1H-(1,2,4)oxadiazolo(4,3-alpha)quinoxalin-1-one (ODQ) (30.0 mumol/l), a guanylyl cyclase inhibitor. However, 3-aminobenzamide (3.0 mmol/l), an inhibitor of poly(ADP-ribose)synthase, did not influence the relaxant effect of ONOO- (1.0 mmol/l). Results of the present study implicate that activation of K-ATP(+) channels and/or cGMP/K-ATP(+) channel interaction might play a role in the relaxant responses to ONOO- in isolated rat anococcygeus muscle Copyright (C) 2002 S. KargerAG, Basel.