THE EFFECT OF PROTEASOME INHIBITOR MG-132 ON BREAST CANCER CELLS ACCORDING TO THE RADIOFREQUENCY FIELD ADAPTIVE RESPONSE

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Koç B., Taşpınar Şimşek E., Gökçen S., Özgür Büyükatalay E., Kayhan H.

The Fourth Annual Conference of Bioem, Rennes, Fransa, 22 - 27 Haziran 2025, ss.45-46, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Rennes
  • Basıldığı Ülke: Fransa
  • Sayfa Sayıları: ss.45-46
  • Gazi Üniversitesi Adresli: Evet

Özet

This study investigates the apoptotic effects of the proteasome inhibitor MG-132 in combination with 900 MHz radiofrequency (RF) field exposure on 4T1 mouse breast cancer cells. Cells were treated with MG-132 alone, RF exposure alone, or a combination of both for 24 and 48 hours. Flow cytometry analysis revealed that MG-132 reduced cell viability in a concentration-dependent manner, with a significant increase in early apoptosis when combined with RF exposure. The results suggest that RF fields may enhance the effectiveness of MG-132 by influencing cellular stress and metabolism. This combination could offer a potential adjunctive approach for breast cancer treatment, warranting further investigation in animal models and with different RF frequencies.