The purpose of this paper is to explore the literature on addressing sexuality and sexual health in nursing practice and using nursing care process for the assessment of sexual problems of individuals. Sexuality is a part of life and being human. Sexual function may be affected negatively owing to disease, treatment or surgery and changes may occur in the sexual function of any individual. In order to maintain the sexual function of individuals and improve the quality of life, health professionals must identify and solve sexual problems. Nurses can use nursing process in determining and addressing the sexual problems of individuals. The literature review was conducted utilizing several databases, selected because of their relevance to the subject under review and including CINAHL, Medline (PubMed) and Nursing Journals (PubMed). Results highlight the benefit of nursing care process in addressing the sexuality and sexual problems of people with various diseases. Nurses are aware that assessing sexuality, diagnosing sexuality problems, and evaluating outcomes of interventions to address patients' sexuality concerns are part of holistic care. However, they often do not perform sexuality assessment in practice. The conclusion is nurses working in accordance with nursing procedures play a key role in achieving success and providing integrated care help individuals to express their sexual problems.