Life-threatening Agranulocytosis, Anemia, and Plasmacytosis After Dipyrone Use for Fever in a Child

Isik M., KAYA Z., Belen F. B., Aktas A. T., TEZER H., Gursel T.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.36, no.1, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1097/mph.0000000000000079
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: dipyrone, agranulocytosis, plasmacytosis, child, DRUG-INDUCED AGRANULOCYTOSIS, BLOOD DYSCRASIAS, METAMIZOLE, THROMBOCYTOSIS, TOXICITY
  • Gazi University Affiliated: Yes

Abstract

Dipyrone or metamizole Na (Novalgin) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world; however, it is banned in developed countries because of severe side effects. Here we present a case of a 4-year-old boy who developed life-threatening agranulocytosis, anemia, and marked plasmacytosis in his bone marrow after dipyrone use for fever, which resolved with steroid therapy.