Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study

Gok M., Kundi H., Kiziltunc E. , Topcuoglu C., Ornek E.

ANGIOLOGY, cilt.69, sa.1, ss.43-48, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 69 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0003319717703835
  • Dergi Adı: ANGIOLOGY
  • Sayfa Sayıları: ss.43-48


We investigated the relationship between endocan (a marker of systemic inflammation) and the development of coronary collateral circulation (CCC) as evaluated by coronary angiography in patients with chronic stable angina pectoris. A total of 90 patients (32 poor CCC and 58 good CCC) were included in this study. Endocan levels were determined using a commercially available sandwich enzyme-linked immunosorbent assay kit with high sensitivity and specificity for detection of human endocan. In multivariate logistic regression analysis, low endocan levels were independently associated with good CCC (P < .001). Moreover, low high-sensitivity C-reactive protein levels were also independently associated with good CCC (P = .020). We found an optimal cutoff point for endocan of 1.7 ng/mL; it predicted the presence of good CCC with a sensitivity of 72.4% and specificity of 65.6% (P < .001). The results of the present study suggest that measurement of endocan level may help clinicians to predict the development of CCC in patients with stable coronary artery disease.