Bile Acid Toxicity and Protein Kinases

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Atıf İçin Kopyala

ENGİN A.

PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, cilt.1275, ss.229-258, 2021 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 1275
• Basım Tarihi: 2021
• Doi Numarası: 10.1007/978-3-030-49844-3_9
• Dergi Adı: PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
• Sayfa Sayıları: ss.229-258
• Gazi Üniversitesi Adresli: Evet

Özet

If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in cell death. Thus, hydrophobic bile acids induce apoptosis in hepatocytes, while hydrophilic bile acids increase intracellular adenosine 3',5'- monophosphate (cAMP) levels and activate mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways to protect hepatocytes from apoptosis.