Bile Acid Toxicity and Protein Kinases


ENGİN A.

PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, cilt.1275, ss.229-258, 2021 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1275
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/978-3-030-49844-3_9
  • Dergi Adı: PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
  • Sayfa Sayıları: ss.229-258

Özet

If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in cell death. Thus, hydrophobic bile acids induce apoptosis in hepatocytes, while hydrophilic bile acids increase intracellular adenosine 3',5'- monophosphate (cAMP) levels and activate mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways to protect hepatocytes from apoptosis.