Bile Acid Toxicity and Protein Kinases


ENGİN A.

PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, vol.1275, pp.229-258, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 1275
  • Publication Date: 2021
  • Doi Number: 10.1007/978-3-030-49844-3_9
  • Title of Journal : PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
  • Page Numbers: pp.229-258

Abstract

If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in cell death. Thus, hydrophobic bile acids induce apoptosis in hepatocytes, while hydrophilic bile acids increase intracellular adenosine 3',5'- monophosphate (cAMP) levels and activate mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways to protect hepatocytes from apoptosis.