Kikuchi-Fujimoto disease in a patient with mediastinal lymphadenopathy mediastinal lenfadenopati ile seyreden bir Kikuchi Fujimoto olgusu

Turan H., Şerefhanoǧlu K., Apilioǧullari B., Aribaş O. K. , Ekici Z., Timurkaynak F., ...Daha Fazla

Turk Toraks Dergisi, cilt.15, sa.2, ss.65-67, 2014 (SCI Expanded İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/ttd.2014.38
  • Dergi Adı: Turk Toraks Dergisi
  • Sayfa Sayıları: ss.65-67


Kikuchi-Fujimoto disease is a benign self-limited syndrome with distinct histopathologic characteristics. Clinical symptoms include cervical lymphadenopathy with tenderness, fever of medium grade, night sweats, nausea, vomiting, and a sore throat. It is a rare disease worldwide. Diagnosis is based on histopathologic findings from an excisional lymph node biopsy. We present the case of a 37-year-old male patient with a fever of 15 days' duration. Clinical examination revealed no other pathologic signs except for oral aphthous lesions and a fever of unknown origin. The patient's fever did not resolve after 15 days' follow-up, and the results of computed tomographic study of the thorax revealed several sites of mediastinal lymphadenopathy. The diagnosis of Kikuchi-Fujimoto disease (histiocytic necrotising lymphadenitis) was based on the results of pathologic examination of the biopsy specimen. The patient's signs and symptoms resolved without antibiotic therapy. This case report of a patient with a fever of unknown origin is presented because of the rare involvement of mediastinal lymphadenopathy without cervical lymphadenopathy. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of the patient who presents with fever and mediastinal lymphadenopathy. © 2014 by Turkish Thoracic Society.