Multi-layered functional membranes for periodontal regeneration: Preparation and characterization

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Gürbüz S. , Demirtas T. T. , Yuksel E., Karakeçili A., Dogan A., Gümüşderelioğlu M.

MATERIALS LETTERS, cilt.178, ss.256-259, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 178
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.matlet.2016.05.054
  • Sayfa Sayıları: ss.256-259


Multi-layered biodegradable membranes (MLMs) were fabricated by combining electrospinning and solvent casting/particulate leaching methods. MLMs possess three layers of different functional properties; poly (caprolactone) (PCL)/nano-hydroxyapatite core layer and PCL/collagen, PCL/collagen-bone morphogenic protein 7 (BMP 7) outer layers on each side of the core layer. MC3T3-E1 cell culture tests showed that osteoblastic differentiation was enhanced on PCL/collagen BMP 7 layer. This facile method presents great potential for fabrication of multi-functional barrier membranes for periodontal regeneration as well as scaffolds possessing different properties to mimic complex extra cellular matrix structures with stable integrity. (C) 2016 Elsevier B.V. All rights reserved.