Multi-layered functional membranes for periodontal regeneration: Preparation and characterization
MATERIALS LETTERS, cilt.178, ss.256-259, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 178
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.matlet.2016.05.054
- Dergi Adı: MATERIALS LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.256-259
- Anahtar Kelimeler: Multilayer structures, Biomaterials, Electrospinning, Solvent casting/particulate leaching, Poly(caprolactone)
- Gazi Üniversitesi Adresli: Evet
Özet
Multi-layered biodegradable membranes (MLMs) were fabricated by combining electrospinning and solvent casting/particulate leaching methods. MLMs possess three layers of different functional properties; poly (caprolactone) (PCL)/nano-hydroxyapatite core layer and PCL/collagen, PCL/collagen-bone morphogenic protein 7 (BMP 7) outer layers on each side of the core layer. MC3T3-E1 cell culture tests showed that osteoblastic differentiation was enhanced on PCL/collagen BMP 7 layer. This facile method presents great potential for fabrication of multi-functional barrier membranes for periodontal regeneration as well as scaffolds possessing different properties to mimic complex extra cellular matrix structures with stable integrity. (C) 2016 Elsevier B.V. All rights reserved.