Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis. IR and H-1 NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and Vn g,j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f,j, p showed statistically significant anti-inflammatory activity.