N-(2-Pyridinyl)-2-[2(3H)-benzazolone-3-YL]acetamides: Synthesis, antinociceptive and anti-inflammatory activity


DOĞRUER D. S. , Unlu S., Yesilada E., Sahin M.

FARMACO, vol.52, no.12, pp.745-750, 1997 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 12
  • Publication Date: 1997
  • Title of Journal : FARMACO
  • Page Numbers: pp.745-750

Abstract

Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis. IR and H-1 NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and Vn g,j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f,j, p showed statistically significant anti-inflammatory activity.