The aim of this histopathologic study was to assess and compare the subcutaneous connective tissue reaction to three different maxillofacial silicone elastomers (Cosmesil, Multisil, Episil). The test materials were directly inserted subcutaneously into the dorsal subcutaneous tissue of Wistar albino rats. Histopathological examinations were done at 7, 30, and 90 days after the implantation procedure. The presence of inflammation, presence of inflammatory giant cells, and the thickness of fibrous connective tissue adjacent to each inserted sample were recorded. Data was evaluated by analysis of variance, Wilcoxon signed ranks test and Kruskal Wallis test. Cosmesil, Multisil and Episil silicone elastomers at 7 days elicited a severe inflammatory reaction. However, these reactions decreased by the 30 and 90 days. All silicone elastomers elicited a moderate inflammatory reaction at 30 and 90 days. There were no significant differences in tissue reaction between the materials at 7, 30, and 90 days (P > 0.05). All the maxillofacial silicone elastomers evaluated can not be assigned a favorable biocompatibility level based on this study's histologic findings.