Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury

ARSLAN M., Comu F. M., KÜÇÜK A., Ozturk L., YAYLAK F.

LIBYAN JOURNAL OF MEDICINE, cilt.7, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3402/ljm.v7i0.18185
  • Dergi Adı: LIBYAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: hepatic ischemia-reperfusion injury, lipid peroxidation, malondialdehyde, superoxide dismutase, erythrocyte deformability, dexmedetomidine, ISCHEMIA/REPERFUSION INJURY, NITRIC-OXIDE, DAMAGE, RATS, MECHANISMS, ANESTHESIA, EXPRESSION, APOPTOSIS, SURGERY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats.