Akademik Veri Yönetim Sistemi
ULTRASOUND QUARTERLY, cilt.39, sa.2, ss.81-85, 2023 (SCI-Expanded)
In this study, we aimed to investigate the correlation of stiffness values of shear-wave elastography (SWE) and histopathological prognostic factors in patients with breast cancer. Between January 2021 and June 2022, SWE images of 138 core-biopsy proven breast cancer lesions from 132 patients were retrospectively reviewed. Histopathogic prognostic factors, including tumor size, histologic grade, histologic type, hormone receptor positivity, human epidermal growth factor receptor (HER2) status, immunohistochemical subtype and Ki-67 index were documented. Elasticity values including mean and maximum elasticity (E-mean and E-max) and lesion-to-fat ratio (E-ratio) were recorded. The association between histopathological prognostic factors and elasticity values were assessed using Mann-Whitney U and Kruskal-Wallis test, and multiple linear regression analysis. Tumor size, histological grade, and Ki-67 index were significantly associated with the E-ratio (P < 0.05). Larger tumor size and higher Ki-67 index also showed significantly higher E-mean and E-max values (P < 0.05). However, hormone receptor positivity, HER2 status, and immunohistochemical subtype were not significantly associated with elasticity values (P > 0.05). Multivariate logistic regression analysis revealed that tumor size was significantly associated with E-mean, E-max, and E-ratio values (P < 0.05). A high Ki-67 index was also significantly associated with high E-ratio values. Larger tumor size and higher Ki-67 index are independently associated with high E-ratio values. Preoperative SWE may improve the performance of conventional ultrasound in predicting prognosis and treatment planning.