Useful agents against aflatoxin B-1 - antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine


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Anar M., Hasanoğlu Özkan E. , Öğütçü H., Ağar G., Şakıyan İ., Sarı N.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.44, pp.853-858, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44
  • Publication Date: 2016
  • Doi Number: 10.3109/21691401.2014.991792
  • Title of Journal : ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Page Numbers: pp.853-858
  • Keywords: antimicrobial properties, aflatoxin B, Mn(III) complexes, mutagenicity, AMINO-ACIDS, EPOXIDATION, GLUTAMINE

Abstract

The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Afl atoxin B ı (AFB ı ) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFB ı -induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFB ı .