Chemoprotective effect of ascorbic acid, alpha-tocopherol, and selenium on cyclophosphamide-induced toxicity in the rat ovarium

Gürgen S. G., Erdogan D., Elmas Ç., Take Kaplanoğlu G., Özer Ç.

NUTRITION, cilt.29, ss.777-784, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.nut.2012.11.004
  • Dergi Adı: NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.777-784
  • Anahtar Kelimeler: Cyclophosphamide, Ovarium, PCNA, GDF-9, Ascorbic acid, alpha-Tocopherol, Selenium, GROWTH-DIFFERENTIATION FACTOR-9, FOLLICLE-STIMULATING-HORMONE, VITAMIN-E, GRANULOSA-CELLS, GLUTATHIONE, CHEMOTHERAPY, TRANSFERASE, INVOLVEMENT, DEFICIENCY, EXPRESSION
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: The aim of the study was to evaluate the protective efficacy of ascorbic acid, alpha-tocopherol, and selenium by measuring the glutathione (GSH) levels and proliferating cell nuclear antigen (PCNA) and growth differentiation factor-9 (GDF-9) expression in the ovarian tissues of rats treated with cyclophosphamide (CP) therapy.