Chemoprotective effect of ascorbic acid, alpha-tocopherol, and selenium on cyclophosphamide-induced toxicity in the rat ovarium


Gürgen S. G. , Erdogan D., Elmas Ç. , Take Kaplanoğlu G. , Özer Ç.

NUTRITION, cilt.29, ss.777-784, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.nut.2012.11.004
  • Dergi Adı: NUTRITION
  • Sayfa Sayıları: ss.777-784

Özet

Objective: The aim of the study was to evaluate the protective efficacy of ascorbic acid, alpha-tocopherol, and selenium by measuring the glutathione (GSH) levels and proliferating cell nuclear antigen (PCNA) and growth differentiation factor-9 (GDF-9) expression in the ovarian tissues of rats treated with cyclophosphamide (CP) therapy.