Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium


Tosun F., Kizilay C. A. , Erol K., KILIÇ F. S. , KÜRKÇÜOĞLU M., BAŞER K. H. C.

FOOD CHEMISTRY, cilt.107, ss.990-993, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 107 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.foodchem.2007.08.085
  • Dergi Adı: FOOD CHEMISTRY
  • Sayfa Sayıları: ss.990-993

Özet

The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice. Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, H-1 NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%. Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC-MS. (c) 2007 Elsevier Ltd. All rights reserved.