This paper recommends a simple and reliable method for the determination of some toxic elements in fish muscles. They are present in the aquatic food chain, becoming dangerous for humans too, as a consequence of consumption of marine products. The experiments were performed simultaneously on dropping mercury electrode (DME) and hanging mercury drop electrode (EMDE) using differential pulse polarography (DPP) and differential pulse anodic stripping voltammetry (DPASV). In this method, the three different fish samples were digested in HNO3: HClO4 (4:1) by wet digestion procedure. The DP polarograms of digested fish samples in 0.1 M HCl solution gave peaks for Cu, Pb, Se and Zn at -0.15 V, -0.35 V, -0.50 V and -0.98 V, respectively. The method was applied to 0.5 mL of three different digested fish sample and 0.61 - 1.12 mu g Cu/g, 1.70 - 5.90 mu g Pb/g, 1.10 - 5.10 mu g Se/g and 27.9 - 51.2 mu g Zn/g dry mass could be determined with the maximum relative standard deviations of 6.3 %, 9.5 %, 6.3 % and 5.7 %, respectively and with a 90% confidence interval (n=5). A recovery test performed for the accuracy of the method was between 96-98 %.