THE COMPARISON OF THEOPHYLLINE PERMEABILITIES FROM HYDROPHILIC POLYHYDROXYETHYLMETHACRYLATE AND HYDROPHOBIC POLYURETHANE, POLYVINYLCHLORIDE MEMBRANES


PULAT M.

REACTIVE POLYMERS, vol.24, no.1, pp.59-63, 1994 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 1994
  • Doi Number: 10.1016/0923-1137(94)90137-6
  • Title of Journal : REACTIVE POLYMERS
  • Page Numbers: pp.59-63

Abstract

In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37-degrees-C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA and PU and PVC membranes.