New diterpene isopimara-7,15-dien-19-oic acid and its prolyl endopeptidase inhibitory activity

Atta-Ur-Rahman A., Akhtar M., Choudhary M., Tsuda Y., Yasin A., Sener B., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.19, sa.1, ss.13-22, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/14786410310001643885
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-22
  • Anahtar Kelimeler: prolyl endopeptidase inhibition, Fritillaria imperialis, isopimaric acid, X-ray diffraction, BULBS
  • Gazi Üniversitesi Adresli: Hayır

Özet

The ethanolic extract of the bulbs of Fritillaria imperialis was subjected to fractionation by solvent-solvent extraction. The nonpolar fraction showed inhibitory activity against prolyl endopeptidase (PEP) (EC.3.4.21.26). a large intracellular enzyme that preferentially hydrolyze proline-containing oligopeptidase at the carboxylic side of a prolyl residue. We have isolated a diterpenoid isopimara-7,15-dien-19-oic acid (1) from the nonpolar fraction of F. imperialis, and on methylation of compound 1, a methylester 2 was obtained which is a known compound previously isolated front Fritillaria thunbergii. The present article describes the isolation and structural elucidation of isopimara-7,15-dien-19-oic acid (1) by single-crystal X-ray diffraction techniques along with its prolyl endopeptidase inhibitory activity.